The lung microbiome regulates brain autoimmunity

Uncategorized Mar 04, 2022

This research was originally published in 2022 by Leon Hosang, Roger Cugota Canals, Felicia Joy van der Flier, Jacqueline Hollensteiner, Rolf Daniel, Alexander Flügel & Francesca Odoardi 

 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT:

Lung infections and smoking are risk factors for multiple sclerosis, a T-cell-mediated autoimmune disease of the central nervous system1. In addition, the lung serves as a niche for the disease-inducing T cells for long-term survival and for maturation into migration-competent effector T cells2. Why the lung tissue in particular has such an important role in an autoimmune disease of the brain is not yet known. Here we detected a tight interconnection between the lung microbiota and the immune reactivity of the brain. A dysregulation in the lung microbiome significantly influenced the susceptibility of rats to developing autoimmune disease of...

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Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities

Uncategorized Mar 04, 2022

This research was originally published in 2021 by George Hajishengallis  and Triantafyllos Chavakis 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT:

Periodontitis, a major inflammatory disease of the oral mucosa, is epidemiologically associated with other chronic inflammation-driven disorders, including cardio-metabolic, neurodegenerative and autoimmune diseases and cancer. Emerging evidence from interventional studies indicates that local treatment of periodontitis ameliorates surrogate markers of comorbid conditions. The potential causal link between periodontitis and its comorbidities is further strengthened by recent experimental animal studies establishing biologically plausible and clinically consistent mechanisms whereby periodontitis could initiate or aggravate a comorbid condition. This multi-faceted ‘mechanistic causality’ aspect of the link between periodontitis and comorbidities is the focus of...

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Oral Administration of Porphyromonas gingivalis Alters the Gut Microbiome and Serum Metabolome

Uncategorized Mar 04, 2022

This research was originally published in 2018 by Tamotsu Kato, Kyoko Yamazaki, Mayuka Nakajima, Yasuhiro Date, Jun Kikuchi, Koji Hase, Hiroshi Ohno, Kazuhisa Yamazakia.

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT:

Periodontal disease induced by periodontopathic bacteria likePorphy-romonas gingivalisis demonstrated to increase the risk of metabolic, inflammatory,and autoimmune disorders. Although precise mechanisms for this connection havenot been elucidated, we have proposed mechanisms by which orally administeredperiodontopathic bacteria might induce changes in gut microbiota composition, bar-rier function, and immune system, resulting in an increased risk of diseases charac-terized by low-grade systemic inflammation. Accumulating evidence suggests a pro-found effect of altered gut metabolite profiles on overall host health. Therefore, it ispossible thatP. gingivaliscan affect these metabolites. To test...

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Association between periodontitis and severity of COVID-19 infection: A case–control study

Uncategorized Oct 27, 2021

This research was originally published in 2021 by Nadya Marouf,Wenji Cai,Khalid N. Said,Hanin Daas,Hanan Diab,Venkateswara Rao Chinta,Ali Ait Hssain,Belinda Nicolau,Mariano Sanz,Faleh Tamimi.

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT:

Aim

COVID-19 is associated with an exacerbated inflammatory response that can result in fatal outcomes. Systemic inflammation is also a main characteristic of periodontitis. Therefore, we investigated the association of periodontitis with COVID-19 complications.

Materials and Methods

A case–control study was performed using the national electronic health records of the State of Qatar between February and July 2020. Cases were defined as patients who suffered COVID-19 complications (death, ICU admissions or assisted ventilation), and controls were COVID-19 patients discharged without major complications. Periodontal conditions were assessed using dental radiographs from the same database. Associations...

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The Oral Microbiome in Periodontal Health

Uncategorized Oct 14, 2021

This research was originally published in 2021 by Magdalena LenartovaBarbora TesinskaTatjana JanatovaOndrej HrebicekJaroslav MysakJiri Janata and Lucie Najmanova

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT:

The estimation of oral microbiome (OM) taxonomic composition in periodontally healthy individuals can often be biased because the clinically periodontally healthy subjects for evaluation can already experience dysbiosis. Usually, they are included just based on the absence of clinical signs of periodontitis. Additionally, the age of subjects is used to be higher to correspond well with tested groups of patients with chronic periodontitis, a disorder typically associated with aging. However, the dysbiosis of the OM precedes the clinical signs of the disease by many months or even years. The absence of periodontal pockets thus does not necessarily mean also good periodontal health and the obtained...

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Progress in Oral Microbiome Related to Oral and Systemic Diseases: An Update

Uncategorized Oct 14, 2021

This research was originally published in 2021 by Yeon-Hee Lee, Sang Wan Chung, Q-Schick Auh, Seung-Jae Hong, Yeon-Ah Lee, Junho Jung, Gi-Ja Lee, Hae Jeong Park, Seung-Il Shin and Ji-Youn Hong 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT:

The human oral microbiome refers to an ecological community of symbiotic and pathogenic microorganisms found in the oral cavity. The oral cavity is an environment that provides various biological niches, such as the teeth, tongue, and oral mucosa. The oral cavity is the gateway between the external environment and the human body, maintaining oral homeostasis, protecting the mouth, and preventing disease.

On the flip side, the oral microbiome also plays an important role in the triggering, development, and progression of oral and systemic diseases. In recent years, disease diagnosis through the analysis of the human oral microbiome has been realized with the recent development of innovative detection...

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Amoeba linked to severe gum disease

Uncategorized Sep 30, 2021

This research was originally published in 2021 by the editor of the Bite Magazine

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT:

For the first time, researchers from Germany have shown that a unicellular parasite commonly found in the mouth plays a role in both severe tissue inflammation and tissue destruction. 

The team from Charité – Universitätsmedizin Berlin—and whose findings are published in the Journal of Dental Researchfound that most patients with severe and recurrent periodontitis (gum disease) showed an increased presence of the amoeba Entamoeba gingivalis inside their oral cavities. Once the parasite has invaded the gingival tissue, it feeds on its cells and causes tissue destruction. 

Read Full Article Here

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The Oral Microbiome in Periodontal Health

Uncategorized Sep 27, 2021

This research was originally published in 2021 by Magdalena Lenartova, Barbora Tesinska, Tatjana Janatova, Ondrej Hrebicek Jaroslav Mysak , Jiri Janata and Lucie Najmanova

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

The estimation of oral microbiome (OM) taxonomic composition in periodontally healthy individuals can often be biased because the clinically periodontally healthy subjects for evaluation can already experience dysbiosis. Usually, they are included just based on the absence of clinical signs of periodontitis. Additionally, the age of subjects is used to be higher to correspond well with tested groups of patients with chronic periodontitis, a disorder typically associated with aging. However, the dysbiosis of the OM precedes the clinical signs of the disease by many months or even years. The absence of periodontal pockets thus does not necessarily mean also good periodontal health and the obtained image of...

Continue Reading...

Progress in Oral Microbiome Related to Oral and Systemic Diseases: An Update

Uncategorized Sep 27, 2021

This research was originally published in 2021 by Yeon-Hee Lee , Sang Wan Chung , Q-Schick Auh , Seung-Jae Hong , Yeon-Ah Lee , Junho Jung , Gi-Ja Lee, Hae Jeong Park  , Seung-Il Shin  and Ji-Youn Hong 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

The human oral microbiome refers to an ecological community of symbiotic and pathogenic microorganisms found in the oral cavity. The oral cavity is an environment that provides various biological niches, such as the teeth, tongue, and oral mucosa. The oral cavity is the gateway between the external environment and the human body, maintaining oral homeostasis, protecting the mouth, and preventing disease. On the flip side, the oral microbiome also plays an important role in the triggering, development, and progression of oral and systemic diseases. In recent years, disease diagnosis through the analysis of the human oral microbiome has been realized with the recent development of...

Continue Reading...

Chronic disease management and care coordination: Expanding the dental provider’s role

Uncategorized Jul 31, 2021

This research was originally published in 2021 by Alicia Webb, MSHI, BTDH, RDH and Shannon Sommers, MSHI, BTDH, RDH.

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

 

As of 2018, approximately one-half of adult patients in the United States have at least one of 10 common chronic diseases.1 The COVID-19 pandemic has proven that more patients have multiple chronic conditions and require infection-related treatment, while at the same time fewer patients are seeking preventive care.2 Subsequently, it is estimated there will be a shortage of up to 35,600 primary care providers by 2025.1

Considering that dental practitioners are formally educated in the biomedical sciences, and that approximately 9% of patients visit a dentist but not a physician,1 dental providers are well positioned to examine the role that chronic diseases play in oral health outcomes and could be the answer to addressing these issues.3 Currently,...

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