Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

This research was originally published in 2018 by Vladimir Ilievski,Paulina K. Zuchowska,Stefan J. Green,Peter T. Toth,Michael E. Ragozzino,Khuong Le,Haider W. Aljewari,Neil M. O’Brien-Simpson,Eric C. Reynolds,Keiko Watanabe. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

The results from cross sectional and longitudinal studies show that periodontitis is closely associated with cognitive impairment (CI) and Alzhemer’s Disease (AD). Further, studies using animal model of periodontitis and human post-mortem brain tissues from subjects with AD strongly suggest that a gram-negative periodontal pathogen, Porphyromonas gingivalis (Pg) and/or its product gingipain is/are translocated to the brain. However, neuropathology resulting from Pg oral application is not known. In this work, we tested the hypothesis that repeated exposure of wild type C57BL/6 mice to orally administered Pg results in neuroinflammation,...

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Microflora of Endodontic Infection - A Review

This research was originally published in 2018 by Shruthi H Attavar, Mithra N Hegde. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

The aim of endodontic treatment is to identify and eradicate the etiological factor responsible for infection. Thorough Cleaning of the root canalsystem by instrumentation, irrigation and removal of endodontic biofilm is considered as most important factor to prevent and treat the disease. The apical delta, apical fins, isthmuses present in the root canal provide an excellent environment for formation of biofilm and is one of the main cause for reinfection. The following review article explores the role the Endodontic microflora and its role in the success of endodontic therapy .

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Impact of Endodontically Treated Teeth on Systemic Diseases

This research was originally published in 2019 by Johann Lechner and Volker von Baehr. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT
Background: This study compares the radiographic distribution of apical periodontitis (AP) in rootfilled and endodontically treated teeth among healthy controls and patients with systemic diseases; the incidence of AP was almost twice as high in the latter group.

Objective: The question arises as to whether the biogenic amines (mercaptan/thioether/hydrogen sulfide) originating from endodontically treated teeth have systemic, subtoxic and immunological effects.

Method: In order to determine this, local hydrogen sulfide measurements of endodontically treated teeth were combined with the laboratory serum analyses of modified proteins to assess the relationship of these compounds with type IV immune reactions.

Results: It was found that 42.5% of the group with systemic diseases showed immunological disturbance as...

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Comparison of Endotoxin Levels Found in Primary and Secondary Endodontic Infections

This research was originally published in 2019 by Brenda P.F.A. Gomes, DDS, MSc, PhD, Marcos S. Endo, DDS, MSc, and Frederico C. Martinho, DDS, MSc, PhD.

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

Introduction: This clinical study was conducted to compare the levels of endotoxins (lipopolysaccharides [LPSs]) found in primary and secondary endodontic infections with apical periodontitis by correlating LPS contents with clinical/radiographic findings. In addition, the presence of target gram-negative anaerobic bacteria was also investigated.

Methods: Samples were taken from 15 root canals with primary infections and 15 with secondary infections by using paper points. The limulus amebocyte lysate assay was used to quantify endotoxins, and the polymerase chain reaction technique (16S rDNA) was used for bacterial investigation.

Results: Endotoxins were detected in 100% of the root canal samples collected from primary (15/15) and secondary (15/15)...

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We may finally know what causes Alzheimer’s – and how to stop it

This research was originally published in 2019 by Debora Mackenzie. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

AFTER decades of disappointment, we may have a new lead on fighting Alzheimer’s disease. Compelling evidence that the condition is caused by a bacterium involved in gum disease could prove a game-changer in tackling one of medicine’s biggest mysteries, and lead to effective treatments or even a vaccine.

As populations have aged, dementia has skyrocketed to become the fifth biggest cause of death worldwide. Alzheimer’s constitutes some 70 per cent of these cases (see “What is Alzheimer’s disease”), yet we don’t know what causes it. The condition, which results in progressive loss of memory and cognitive function, usually over a decade or so, is devastating both to those who have it and to their loved ones.

The condition often involves the accumulation of two types of proteins –...

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Alzheimer’s disease - a neurospirochetosis. Analysis of the evidence following Koch’s and Hill’s criteria.

This research was originally published in 2011 by Judith Miklossy. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

It is established that chronic spirochetal infection can cause slowly progressive dementia, brain atrophy and amyloid deposition in late neurosyphilis. Recently it has been suggested that various types of spirochetes, in an analogous way to Treponema pallidum, could cause dementia and may be involved in the pathogenesis of Alzheimer’s disease (AD). Here, we review all data available in the literature on the detection of spirochetes in AD and critically analyze the association and causal relationship between spirochetes and AD following established criteria of Koch and Hill. The results show a statistically significant association between spirochetes and AD (P = 1.5 × 10-17, OR = 20, 95% CI = 8-60, N = 247). When neutral techniques recognizing all types of spirochetes were used, or the highly prevalent periodontal...

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Ignoring Dental Health Can Increase Diabetes Risk: These Dangerous Diseases Can Be Caused by Poor Oral Hygiene

This research was originally published in 2018 by Sandhya Raghavan. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

Keeping your teeth clean is no longer just an oral hygiene is no longer just an oral hygiene issue. Not brushing correctly or ignoring your teeth can increase your risk of diabetes, according to a new study Dr. Raynald Samoa from the City of Hope National Medical Center in Duarte, California revealed that the researchers found a positive connection between poor glucose tolerance and missing teeth

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Studies link gum disease with pancreatic cancer

This research was originally published in 2018. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

The bacteria that cause periodontitis may also play a part in the onset of pancreatic cancer, according to new research coming out of Scandinavia.

Researchers at the University of Helsinki and the Helsinki University Hospital, Finland, and the Karolinska Institutet, Sweden have been investigating the role of bacteria causing periodontitis in the development of oral and certain other cancers, as well as the link between periodontitis and cancer mortality on the population level.

Their latest study, published last month in the British Journal of Cancer, has for the first time proved the existence of a mechanism on the molecular level through which the bacteria associated with periodontitis, Treponema denticola (Td), may also have an effect on the onset of cancer.



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Advanced gum disease increases risk for lung, colorectal cancer

This research was originally published in 2018 by Dominique S. Michaud and Elizabeth A. Platz. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

Individuals with severe periodontitis, or gum disease, had increased risk for developing cancer compared with individuals with mild or no gum disease, according to published findings.

Those with severe periodontitis had more than double the risk for developing lung cancer and twofold higher risk for colorectal cancer, the research showed.

Periodontal disease can cause bacteremia, endotoxemia and systemic low-grade inflammation. There is accumulating evidence that these conditions are contributing to chronic diseases, including heart disease, rheumatoid arthritis and cancer,” Dominique S. Michaud, ScD, professor of public health and community medicine at Tufts University School of Medicine, told HemOnc Today. “The question of...

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Managing Atherosclerotic Disease: Medical and Dental Collaboration- The New Standard of Care

This research was originally published in 2018 by John Kempton DDS. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

Medicine and dentistry have long been aware of the connection, association, and direct links between high-risk periodontal pathogens and cardiovascular disease. Knowledge alone has a limited potential to change chronic disease outcomes unless it leads to new clinical practices. Effective and proven new protocols to identify and mitigate virulent periodontal microbes are available today. A small percentage of dentists have implemented these practices and the majority of physicians are unaware of their existence. In the end, one of the significant causes or perpetuators of atherosclerotic vascular disease is left undiagnosed and under treated.

Periodontitis is a polymicrobial, systemic, infectious, and inflammatory disease with genetic expressions. When medical colleagues are faced with an infectious disease, their effective...

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