Gum infections tied to increased risk of stomach cancer precursor

This research was originally published in 2017 by Lisa Rapaport. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

(Reuters Health) - Gum infections may increase people’s risk for sores in the digestive tract that can lead to stomach cancer, a small study suggests.

Researchers focused on what’s known as periodontal disease, serious infections in the mouth caused by bacteria in dental plaque. Daily brushing and flossing can prevent gingivitis, the milder form of periodontal disease, but untreated cases can lead to permanent damage to the gums and bone.

The new study involved 35 people with so-called precancerous lesions: abnormal cells or sores in the digestive tract where cancer is more likely to occur compared to normal tissue. The researchers also studied a control group of 70 similar people who didn’t have these lesions.

Overall, 32 percent of people with precancerous gastric lesions had the kind of bleeding during dental...

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A MYSTERIOUS BACTERIUM MAY BE A CRITICAL PART OF CANCER : COULD WE TREAT SOME CANCERS WITH A SIMPLE ANTIBIOTIC?

This research was originally published in 2017 by DOM GALEON. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

The Case of the Traveling Bacteria

In 2011, two researchers stumbled upon an intriguing find. In separate studies, Dr. Matthew Meyerson from the Dana-Farber Cancer Institute and Dr. Robert A. Holt from the Simon Fraser University in British Columbia found bacteria that’s normally in the mouth, called Fusobacteria, in human colon cancers.

Six years later, in a new study published in the journal Science, Meyerson and colleagues have confirmed the presence of Fusobacteria in up to half of all colon tumors. The researchers extensively studied human colon tumors that have metastasized to the liver. They found that tumors that have been infected with Fusobacteria continued to be so, even in the liver.

On the other hand, those cancer cells that originally didn’t have the bacteria remained...

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Research may explain why gum disease is linked to heart problems

This research was originally published in 2017. 

We have curated this article as a reference point for The Larkin Protocol. 

ABSTRACT

Heart disease and fatty clogs in the arteries go hand in hand. But new evidence suggests the fatty molecules might come not only from what you eat, but from the bacteria in your mouth, report UConn scientists in the 16 August issue of the Journal of Lipid Research. The research may explain why gum disease is associated with heart trouble.

Heart attacks and strokes are the crises we notice, but they result from a slow process of atherosclerosis, the hardening and clogging of the arteries with fatty substances called lipids. Immune cells stick to the walls of blood vessels, scavenge lipids, and multiply. The blood vessel walls inflame and thicken as the smooth muscle cells lining them change, swelling and dividing to create plaques, clogs, and warty growths called atheromas.

For a very long time, doctors and researchers assumed that the...

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Mouth bacteria linked to esophageal cancer

This research was originally published in 2017 by Catharine Paddock, Ph.D. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

An analysis of microbes sampled from the mouths of more than 120,000 people has found that two types of bacteria that lead to gum disease are also linked to higher risk of esophageal cancer.

The study — led by NYU Langone Health’s Perlmutter Cancer Center in New York, NY — also reveals that some types of mouth bacteria are linked to lower risk of esophageal cancer.

Reporting in the journal Cancer Research, the researchers note that they ruled out potential effects from smoking, alcohol, and body mass index (BMI) when they analyzed the data.

Senior investigator of the study Jiyoung Ahn, an associate professor and epidemiologist at NYU School of Medicine, believes that the findings will take us closer to establishing the causes of esophageal cancer.

She says that this is...

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Periodontal disease and atherosclerosis: Strengthening the oral-systemic link

This research was originally published in 2017 by Richard H. Nagelberg, DDS. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

A RECENTLY PUBLISHED STUDY IN THE MEDICAL JOURNAL, Anaerobe, investigated the link between the presence of eight periodontal pathogens and their virulence genes to atheromatous plaques in patients with ischemic heart disease. (1)Many studies have looked at this link; however, the previous studies were commonly limited to the mere presence of oral bacteria.

This study looked at the bacteria and the bacterial genetic coding for virulence factors. The significance of inclusion of the virulence genes in this study is that it adds an additional level of credibility to the conclusions and insight into the mechanisms involved in the association between the bacteria and atheromatous plaques.

Subgingival and atheromatous plaque samples were obtained from 65 ischemic heart disease patients. The samples that were...

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History of Periodontitis Diagnosis and Edentulism as Predictors of Cardiovascular Disease, Stroke, and Mortality in Postmenopausal Women

This research was originally published in 2017 by Michael J. LaMonte, Robert J. Genco, Kathleen M. Hovey, Robert B. Wallace, Jo L. Freudenheim, Dominique S. Michaud, Xiaodan Mai, Lesley F. Tinker, Christian R. Salazar, Christopher A. Andrews, Wenjun Li, Charles B. Eaton, Lisa W. Martin, and Jean Wactawski‐Wende. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

Background

Few studies have reported associations between periodontitis and cardiovascular disease (CVD) risk in older women, which is the objective of the present investigation.

Methods and Results

Participants were 57 001 postmenopausal women ages 55 to 89 years (mean 68 years; >85% 60 and older) who were enrolled (1993–1998) in the Women's Health Initiative Observational Study, and were without known CVD when history of periodontitis and edentulism was assessed by questionnaire at study Year‐5 (1998–2003). There were 3589...

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An update on bleach swishing: Reviewing the literature on diluted bleach rinsing

This research was originally published in 2015 by LYNNE SLIM, RDH, BSDH, MSDH. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Sometimes my analogies are a bit of a stretch, but it's a good way to introduce a controversial topic. Like many women around the globe, I couldn't get enough of the trilogy Fifty Shades of Grey. I pretty much ignored everyone around me, including my dachshunds, until the very last page. What fascinated me most about the book, however, was the entire Fifty Shades phenomenon, and I even read somewhere that there's a magazine devoted to this obsession.

A phenomenon in dentistry worth discussing is the practice of using diluted bleach as a mouth rinse. It appears to be more common in Southern California where the Danish periodontist and professor, Dr. Jorgen Slots, resides (but I may be wrong in making this assumption). In chatting yesterday with a good friend, Renee Marchant, RDH, from Northern...

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Subgingival Microbial and Inflammatory Cell Morphotypes Associated with Chronic Periodontitis Progression in Treated Adults.

This research was originally published in 2015 by Keyes PH, Rams TE. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Objective

In a secondary data analysis, this pilot study evaluated the relationship between subgingival biofilm morphotypes and chronic periodontitis progression in treated adults.

Methods

Periodontal parameters in 47 adults with chronic periodontitis were assessed by a calibrated examiner at baseline and a mean 4.5 years after a non-surgical periodontal therapy regimen. Microbial and inflammatory cell morphotypes in subgingival biofilm specimens from each patient were evaluated with phase-contrast microscopy at baseline, and at post-treatment intervals. Chronic periodontitis progression in patients was defined as ≥ 2 teeth exhibiting ≥ 3 mm interproximal clinical periodontal attachment loss from baseline evaluations. Bivariate and odds ratio analysis assessed baseline and post-treatment variables relative to chronic...

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Rheumatoid Arthritis and Periodontal Disease: A Rheumatologist's Perspective

This research was originally published in 2014 by Elliot D. Rosenstein, Laura J. Kushner & Neil Kramer. 

We have curated this article as a reference point for The Larkin Protocol.

 
ABSTRACT

Despite advances in our understanding of the inflammatory events that underlie rheumatoid arthritis (RA), which have led to targeted therapies that more effectively control the condition, the etiology of RA is not fully understood. With the discovery that serum antibodies to citrullinated peptides (ACPA) are highly specific for RA and that Porphyromonas gingivalis, the major pathogen responsible for periodontitis (PD), contains the enzyme responsible for the citrullination of peptides, a plausible explanation for observations of increased incidence and severity of PD in RA patients and an appreciation of pathogenic similarities between the two conditions has emerged. Studies of the effect of RA treatment on the severity of PD have been limited and conflicting,...

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Oxidative Stress Parameters in Saliva and Its Association with Periodontal Disease and Types of Bacteria

This research was originally published in 2015 by Jose Manuel Almerich-Silla, Jose María Montiel-Company, Sara Pastor, Felipe Serrano, Miriam Puig-Silla, and Francisco Dasí. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Objective. To determine the association between oxidative stress parameters with periodontal disease, bleeding, and the presence of different periodontal bacteria. Methods. A cross-sectional study in a sample of eighty-six patients, divided into three groups depending on their periodontal status. Thirty-three with chronic periodontitis, sixteen with gingivitis, and thirty-seven with periodontal healthy as control. Oxidative stress biomarkers (8-OHdG and MDA), total antioxidant capacity (TAOC), and the activity of two antioxidant enzymes (GPx and SOD) were determined in saliva. Subgingival plaque samples were obtained from the deepest periodontal pocket and PCR was used...

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