High Lp-PLA2 Doubles Risk for Alzheimer’s

This research was originally published in 2015 by Daniel L. Sindelar, DMD. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Researchers in Texas have just released groundbreaking new information about inflammatory biomarkers and their relationship to Alzheimer’s disease.Their results were published in Alzheimer’s & Dementia.

 The study, which involved nearly 400 subjects, examined the relationship between Lipoprotein-associated phospholipase A2 (Lp-PLA2) and homocysteine (Hcy) and incidence of Alzheimer’s disease.

Lp-PLA2 indicates if the arteries around the heart are inflamed. The PLAC® Test, which measures Lp-PLA2, is considered the most important test in assessing risk for heart attack and stroke, and more indicative of a future cardiovascular event than cholesterol testing.

After adjustment for age, sex, and BMI, subjects with Lp-PLA2 levels above the median were almost twice as...

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Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis

This research was originally published in 2016 by Kosuke Mima, Reiko Nishihara, Zhi Rong Qian, Yin Cao, Yasutaka Sukawa, Jonathan A Nowak, Juhong Yang, Ruoxu Dou, Yohei Masugi, Mingyang Song, Aleksandar D Kostic, Marios Giannakis, Susan Bullman, Danny A Milner, Hideo Baba, Edward L Giovannucci, Levi A Garraway, Gordon J Freeman, Glenn Dranoff, Wendy S Garrett, Curtis Huttenhower, Matthew Meyerson, Jeffrey A Meyerhardt, Andrew T Chan, Charles S Fuchs, Shuji Ogino. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Objective Accumulating evidence links the intestinal microbiota and colorectal carcinogenesis. Fusobacterium nucleatum may promote colorectal tumour growth and inhibit T cell-mediated immune responses against colorectal tumours. Thus, we hypothesised that the amount of F. nucleatum in colorectal carcinoma might be associated with worse clinical outcome.

Design We used molecular pathological epidemiology...

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Management of diabolical diabetes mellitus and periodontitis nexus: Are we doing enough?

This research was originally published in 2016 by Abhijit N Gurav. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Periodontitis is the commonest oral disease affecting population worldwide. This disease is notorious for the devastation of tooth supporting structures, ensuing in the loss of dentition. The etiology for this disease is bacterial biofilm, which accumulates on the teeth as dental plaque. In addition to the biofilm microorganisms, other factors such as environmental, systemic and genetic are also responsible in progression of periodontitis. Diabetes mellitus (DM) is metabolic disorder which has an impact on the global health. DM plays a crucial role in the pathogenesis of periodontitis. Periodontitis is declared as the “sixth” major complication of DM. Evidence based literature has depicted an enhanced incidence and severity of periodontitis in subjects with DM. A “two way” relationship has been purported...

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Porphyromonas gingivalis is the most abundant species detected in coronary and femoral arteries

This research was originally published in 2017 by J-L C Mougeot, C B Stevens, B J Paster, M T Brennan, P B Lockhart, F K B Mougeot.

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

An association between oral bacteria and atherosclerosis has been postulated. A limited number of studies have used 16S RNA gene sequencing-based metagenomics approaches to identify bacteria at the species level from atherosclerotic plaques in arterial walls. The objective of this study was to establish detailed oral microbiome profiles, at both genus and species level, of clinically healthy coronary and femoral artery tissues from patients with atherosclerosis. Tissue specimens were taken from clinically non-atherosclerotic areas of coronary or femoral arteries used for attachment of bypass grafts in 42 patients with atherosclerotic cardiovascular disease. Bacterial DNA was sequenced using the MiSeq platform, and sequence reads were screened in silico for...

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The Role of Oral and Dental Foci in Systemic Diseases

This research was originally published in 2020 by Nelli Yildirimyan, DDS. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

Kidney Disease

Chronic kidney disease (CKD) is defined as reduced kidney function lasting longer than 3 months, and it is a major global health burden. In its early stages, CKD is frequently asymptomatic, but it presents with increased morbidity and mortality when kidney function becomes severely compromised. [37]

 

Patients with CKD commonly present with poor oral health and have a high prevalence for oral infections. [2, 38] This may lead to systemic inflammation, infection, protein wasting, and, as previously mentioned, atherosclerotic lesions



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The Role of Oral and Dental Foci in Systemic Diseases

This research was originally published in 2020 by Nelli Yildirimyan, DDS. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Cardiovascular and Cerebrovascular Disease

The most common cause of mortality worldwide is cerebrovascular disease (CVD), which includes coronary heart disease (CHD), congestive heart failure, CVD and stroke, peripheral artery diseases, carotid artery diseases, and aortoiliac disease. [5The primary cause of both CHD and CVD is atherosclerosis, which is defined as the pathologic narrowing of arteries due to the deposition of cholesterol and its products. [2Many systematic reviews and a scientific statement from the American Heart Association state the possible role of poor oral health on the elevated risk of CHD. [6Periodontal bacterial infections may permit pathogens to colonize distant sites; therefore, the association between certain periodontal pathogens and coronary artery disease...

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The Role of Oral and Dental Foci in Systemic Diseases

This research was originally published in 2020 by Nelli Yildirimyan, DDS. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Foci of infection in the oral cavity and their relationship with the overall health of the human body have been long studied among healthcare practitioners throughout history. The father of medicine, Hippocrates, mentions an association between resolution of arthritis and extraction of a decayed tooth back near 400 BCE. Research on the relationship between oral health and systemic diseases gained rapid acceleration after the death of President Theodore Roosevelt in 1919 from odontogenic sepsis. [1]

The oral cavity, being considered as "the intersection of dentistry and medicine" and "the window to general health", contains some of the most varied and vast flora in the human body and is the main entrance for two systems vital to human function and physiology, the gastrointestinal and respiratory systems. [2]...

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Association between the presence of Treponema denticola and reduced levels of antiatherogenic high density lipoprotein in periodontitis

This research was originally published in 2015 by Carlos M Ardila, Mariana Olarte-Sossa, Astrid Adriana Ariza-Garcés.

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Objective: Dyslipidemia, a disorder in the levels of cholesterol or lipoproteins in the plasma, is a feature of atherosclerosis, leading to cardiovascular disease. The objective of this study was to evaluate whether Tanerella forsythia and Treponema denticola are related to reduced levels of antiatherogenic high density lipoprotein (HDL).

Method and materials: In this cross-sectional study, 108 patients were invited to participate. The diagnosis of chronic periodontitis and the diagnosis of adipose tissue disorders were made based on criteria previously defined. The presence of T forsythia and T denticola was detected by polymerase chain reaction.

Results: A total of 61 women and 19 men with chronic periodontitis, and 18 women and 10 men without periodontitis...

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Relationship Between Prehypertension/Hypertension and Periodontal Disease: A Prospective Cohort Study

This research was originally published in 2015 by Yuya Kawabata, Daisuke Ekuni, Hisataka Miyai, Kota Kataoka, Mayu Yamane, Shinsuke Mizutani, Koichiro Irie, Tetsuji Azuma, Takaaki Tomofuji, Yoshiaki Iwasaki, Manabu Morita. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

BACKGROUND

Most cross-sectional studies have found a significant positive relationship between periodontal disease and prehypertension/hypertension. However, these studies had limitations and there are few prospective cohort studies in young adults. The purpose of this prospective cohort study was to investigate whether periodontal disease was related to prehypertension/hypertension in Japanese university students.

METHODS

Students ( n = 2,588), who underwent health examinations before entering university and before graduation, were included in the analysis. The association between periodontal disease such as the percentage of bleeding on probing (BOP) and...

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Molecular Analysis of Oral Bacteria in Heart Valve of Patients With Cardiovascular Disease by Real-Time Polymerase Chain Reaction

This research was originally published in 2015 by Oliveira, Francisco Artur Forte DDS, MSc; Forte, Clarissa Pessoa Fernandes DDS, MSc; Silva, Paulo Goberlânio de Barros DDS, MSc; Lopes, Camile B. DDS, MSc; Montenegro, Raquel Carvalho PhD; Santos, Ândrea Kely Campos Ribeiro dos PhD; Sobrinho, Carlos Roberto Martins Rodrigues MD, PhD; Mota, Mário Rogério Lima DDS, PhD; Sousa, Fabrício Bitu DDS, PhD; Alves, Ana Paula Negreiros Nunes DDS, PhD. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Structural deficiencies and functional abnormalities of heart valves represent an important cause of cardiovascular morbidity and mortality, and a number of diseases, such as aortic stenosis, have been recently associated with infectious agents. This study aimed to analyze oral bacteria in dental plaque, saliva, and cardiac valves of patients with cardiovascular disease. Samples of supragingival plaque, subgingival plaque,...

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