An update on bleach swishing: Reviewing the literature on diluted bleach rinsing

This research was originally published in 2015 by LYNNE SLIM, RDH, BSDH, MSDH. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Sometimes my analogies are a bit of a stretch, but it's a good way to introduce a controversial topic. Like many women around the globe, I couldn't get enough of the trilogy Fifty Shades of Grey. I pretty much ignored everyone around me, including my dachshunds, until the very last page. What fascinated me most about the book, however, was the entire Fifty Shades phenomenon, and I even read somewhere that there's a magazine devoted to this obsession.

A phenomenon in dentistry worth discussing is the practice of using diluted bleach as a mouth rinse. It appears to be more common in Southern California where the Danish periodontist and professor, Dr. Jorgen Slots, resides (but I may be wrong in making this assumption). In chatting yesterday with a good friend, Renee Marchant, RDH, from Northern...

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Subgingival Microbial and Inflammatory Cell Morphotypes Associated with Chronic Periodontitis Progression in Treated Adults.

This research was originally published in 2015 by Keyes PH, Rams TE. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Objective

In a secondary data analysis, this pilot study evaluated the relationship between subgingival biofilm morphotypes and chronic periodontitis progression in treated adults.

Methods

Periodontal parameters in 47 adults with chronic periodontitis were assessed by a calibrated examiner at baseline and a mean 4.5 years after a non-surgical periodontal therapy regimen. Microbial and inflammatory cell morphotypes in subgingival biofilm specimens from each patient were evaluated with phase-contrast microscopy at baseline, and at post-treatment intervals. Chronic periodontitis progression in patients was defined as ≥ 2 teeth exhibiting ≥ 3 mm interproximal clinical periodontal attachment loss from baseline evaluations. Bivariate and odds ratio analysis assessed baseline and post-treatment variables relative to chronic...

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Rheumatoid Arthritis and Periodontal Disease: A Rheumatologist's Perspective

This research was originally published in 2014 by Elliot D. Rosenstein, Laura J. Kushner & Neil Kramer. 

We have curated this article as a reference point for The Larkin Protocol.

 
ABSTRACT

Despite advances in our understanding of the inflammatory events that underlie rheumatoid arthritis (RA), which have led to targeted therapies that more effectively control the condition, the etiology of RA is not fully understood. With the discovery that serum antibodies to citrullinated peptides (ACPA) are highly specific for RA and that Porphyromonas gingivalis, the major pathogen responsible for periodontitis (PD), contains the enzyme responsible for the citrullination of peptides, a plausible explanation for observations of increased incidence and severity of PD in RA patients and an appreciation of pathogenic similarities between the two conditions has emerged. Studies of the effect of RA treatment on the severity of PD have been limited and conflicting,...

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Oxidative Stress Parameters in Saliva and Its Association with Periodontal Disease and Types of Bacteria

This research was originally published in 2015 by Jose Manuel Almerich-Silla, Jose María Montiel-Company, Sara Pastor, Felipe Serrano, Miriam Puig-Silla, and Francisco Dasí. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Objective. To determine the association between oxidative stress parameters with periodontal disease, bleeding, and the presence of different periodontal bacteria. Methods. A cross-sectional study in a sample of eighty-six patients, divided into three groups depending on their periodontal status. Thirty-three with chronic periodontitis, sixteen with gingivitis, and thirty-seven with periodontal healthy as control. Oxidative stress biomarkers (8-OHdG and MDA), total antioxidant capacity (TAOC), and the activity of two antioxidant enzymes (GPx and SOD) were determined in saliva. Subgingival plaque samples were obtained from the deepest periodontal pocket and PCR was used...

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High Lp-PLA2 Doubles Risk for Alzheimer’s

This research was originally published in 2015 by Daniel L. Sindelar, DMD. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Researchers in Texas have just released groundbreaking new information about inflammatory biomarkers and their relationship to Alzheimer’s disease.Their results were published in Alzheimer’s & Dementia.

 The study, which involved nearly 400 subjects, examined the relationship between Lipoprotein-associated phospholipase A2 (Lp-PLA2) and homocysteine (Hcy) and incidence of Alzheimer’s disease.

Lp-PLA2 indicates if the arteries around the heart are inflamed. The PLAC® Test, which measures Lp-PLA2, is considered the most important test in assessing risk for heart attack and stroke, and more indicative of a future cardiovascular event than cholesterol testing.

After adjustment for age, sex, and BMI, subjects with Lp-PLA2 levels above the median were almost twice as...

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Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis

This research was originally published in 2016 by Kosuke Mima, Reiko Nishihara, Zhi Rong Qian, Yin Cao, Yasutaka Sukawa, Jonathan A Nowak, Juhong Yang, Ruoxu Dou, Yohei Masugi, Mingyang Song, Aleksandar D Kostic, Marios Giannakis, Susan Bullman, Danny A Milner, Hideo Baba, Edward L Giovannucci, Levi A Garraway, Gordon J Freeman, Glenn Dranoff, Wendy S Garrett, Curtis Huttenhower, Matthew Meyerson, Jeffrey A Meyerhardt, Andrew T Chan, Charles S Fuchs, Shuji Ogino. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Objective Accumulating evidence links the intestinal microbiota and colorectal carcinogenesis. Fusobacterium nucleatum may promote colorectal tumour growth and inhibit T cell-mediated immune responses against colorectal tumours. Thus, we hypothesised that the amount of F. nucleatum in colorectal carcinoma might be associated with worse clinical outcome.

Design We used molecular pathological epidemiology...

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Management of diabolical diabetes mellitus and periodontitis nexus: Are we doing enough?

This research was originally published in 2016 by Abhijit N Gurav. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Periodontitis is the commonest oral disease affecting population worldwide. This disease is notorious for the devastation of tooth supporting structures, ensuing in the loss of dentition. The etiology for this disease is bacterial biofilm, which accumulates on the teeth as dental plaque. In addition to the biofilm microorganisms, other factors such as environmental, systemic and genetic are also responsible in progression of periodontitis. Diabetes mellitus (DM) is metabolic disorder which has an impact on the global health. DM plays a crucial role in the pathogenesis of periodontitis. Periodontitis is declared as the “sixth” major complication of DM. Evidence based literature has depicted an enhanced incidence and severity of periodontitis in subjects with DM. A “two way” relationship has been purported...

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Porphyromonas gingivalis is the most abundant species detected in coronary and femoral arteries

This research was originally published in 2017 by J-L C Mougeot, C B Stevens, B J Paster, M T Brennan, P B Lockhart, F K B Mougeot.

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

An association between oral bacteria and atherosclerosis has been postulated. A limited number of studies have used 16S RNA gene sequencing-based metagenomics approaches to identify bacteria at the species level from atherosclerotic plaques in arterial walls. The objective of this study was to establish detailed oral microbiome profiles, at both genus and species level, of clinically healthy coronary and femoral artery tissues from patients with atherosclerosis. Tissue specimens were taken from clinically non-atherosclerotic areas of coronary or femoral arteries used for attachment of bypass grafts in 42 patients with atherosclerotic cardiovascular disease. Bacterial DNA was sequenced using the MiSeq platform, and sequence reads were screened in silico for...

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The Role of Oral and Dental Foci in Systemic Diseases

This research was originally published in 2020 by Nelli Yildirimyan, DDS. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

Kidney Disease

Chronic kidney disease (CKD) is defined as reduced kidney function lasting longer than 3 months, and it is a major global health burden. In its early stages, CKD is frequently asymptomatic, but it presents with increased morbidity and mortality when kidney function becomes severely compromised. [37]

 

Patients with CKD commonly present with poor oral health and have a high prevalence for oral infections. [2, 38] This may lead to systemic inflammation, infection, protein wasting, and, as previously mentioned, atherosclerotic lesions



Read full article here

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The Role of Oral and Dental Foci in Systemic Diseases

This research was originally published in 2020 by Nelli Yildirimyan, DDS. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Cardiovascular and Cerebrovascular Disease

The most common cause of mortality worldwide is cerebrovascular disease (CVD), which includes coronary heart disease (CHD), congestive heart failure, CVD and stroke, peripheral artery diseases, carotid artery diseases, and aortoiliac disease. [5The primary cause of both CHD and CVD is atherosclerosis, which is defined as the pathologic narrowing of arteries due to the deposition of cholesterol and its products. [2Many systematic reviews and a scientific statement from the American Heart Association state the possible role of poor oral health on the elevated risk of CHD. [6Periodontal bacterial infections may permit pathogens to colonize distant sites; therefore, the association between certain periodontal pathogens and coronary artery disease...

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