The Role of Oral and Dental Foci in Systemic Diseases

This research was originally published in 2020 by Nelli Yildirimyan, DDS. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Foci of infection in the oral cavity and their relationship with the overall health of the human body have been long studied among healthcare practitioners throughout history. The father of medicine, Hippocrates, mentions an association between resolution of arthritis and extraction of a decayed tooth back near 400 BCE. Research on the relationship between oral health and systemic diseases gained rapid acceleration after the death of President Theodore Roosevelt in 1919 from odontogenic sepsis. [1]

The oral cavity, being considered as "the intersection of dentistry and medicine" and "the window to general health", contains some of the most varied and vast flora in the human body and is the main entrance for two systems vital to human function and physiology, the gastrointestinal and respiratory systems. [2]...

Continue Reading...

Association between the presence of Treponema denticola and reduced levels of antiatherogenic high density lipoprotein in periodontitis

This research was originally published in 2015 by Carlos M Ardila, Mariana Olarte-Sossa, Astrid Adriana Ariza-Garcés.

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Objective: Dyslipidemia, a disorder in the levels of cholesterol or lipoproteins in the plasma, is a feature of atherosclerosis, leading to cardiovascular disease. The objective of this study was to evaluate whether Tanerella forsythia and Treponema denticola are related to reduced levels of antiatherogenic high density lipoprotein (HDL).

Method and materials: In this cross-sectional study, 108 patients were invited to participate. The diagnosis of chronic periodontitis and the diagnosis of adipose tissue disorders were made based on criteria previously defined. The presence of T forsythia and T denticola was detected by polymerase chain reaction.

Results: A total of 61 women and 19 men with chronic periodontitis, and 18 women and 10 men without periodontitis...

Continue Reading...

Relationship Between Prehypertension/Hypertension and Periodontal Disease: A Prospective Cohort Study

This research was originally published in 2015 by Yuya Kawabata, Daisuke Ekuni, Hisataka Miyai, Kota Kataoka, Mayu Yamane, Shinsuke Mizutani, Koichiro Irie, Tetsuji Azuma, Takaaki Tomofuji, Yoshiaki Iwasaki, Manabu Morita. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

BACKGROUND

Most cross-sectional studies have found a significant positive relationship between periodontal disease and prehypertension/hypertension. However, these studies had limitations and there are few prospective cohort studies in young adults. The purpose of this prospective cohort study was to investigate whether periodontal disease was related to prehypertension/hypertension in Japanese university students.

METHODS

Students ( n = 2,588), who underwent health examinations before entering university and before graduation, were included in the analysis. The association between periodontal disease such as the percentage of bleeding on probing (BOP) and...

Continue Reading...

Molecular Analysis of Oral Bacteria in Heart Valve of Patients With Cardiovascular Disease by Real-Time Polymerase Chain Reaction

This research was originally published in 2015 by Oliveira, Francisco Artur Forte DDS, MSc; Forte, Clarissa Pessoa Fernandes DDS, MSc; Silva, Paulo Goberlânio de Barros DDS, MSc; Lopes, Camile B. DDS, MSc; Montenegro, Raquel Carvalho PhD; Santos, Ândrea Kely Campos Ribeiro dos PhD; Sobrinho, Carlos Roberto Martins Rodrigues MD, PhD; Mota, Mário Rogério Lima DDS, PhD; Sousa, Fabrício Bitu DDS, PhD; Alves, Ana Paula Negreiros Nunes DDS, PhD. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Structural deficiencies and functional abnormalities of heart valves represent an important cause of cardiovascular morbidity and mortality, and a number of diseases, such as aortic stenosis, have been recently associated with infectious agents. This study aimed to analyze oral bacteria in dental plaque, saliva, and cardiac valves of patients with cardiovascular disease. Samples of supragingival plaque, subgingival plaque,...

Continue Reading...

Porphyromonas gingivalis Strain Specific Interactions with Human Coronary Artery Endothelial Cells: A Comparative Study

This research was originally published in 2012 by Paulo H. Rodrigues, Leticia Reyes , Amandeep S. Chadda, Myriam Bélanger , Shannon M. Wallet, Debra Akin, William Dunn, Jr, and Ann Progulske-Fox. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

 

Both epidemiologic and experimental findings suggest that infection with Porphyromonas gingivalis exacerbates progression of atherosclerosis. As P. gingivalis exhibits significant strain variation, it is reasonable that different strains possess different capabilities and/or mechanisms by which they promote atherosclerosis. Using P. gingivalis strains that have been previously evaluated in the ApoE null atherosclerosis model, we assessed the ability of W83, A7436, 381, and 33277 to adhere, invade, and persist in human coronary artery endothelial (HCAE) cells. W83 and 381 displayed an equivalent ability to adhere to HCAE cells, which was...

Continue Reading...

Prevalence of periodontal pathogens in coronary atherosclerotic plaque of patients undergoing coronary artery bypass graft surgery

This research was originally published in 2009 by Jaideep Mahendra, Little Mahendra, V. M. Kurian, K. Jaishankar, and R. Mythilli. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

Background

Chronic bacterial infections have been associated with an increased risk for atherosclerosis and coronary artery disease. The ability of oral pathogens to colonize in coronary atheromatous plaque is well known. The aim of our study was to detect the presence of four common periodontal pathogens in coronary plaques. We detected the presence of 16S rRNA of Treponema denticola, Eikenella Corrodens, Porphyromonas gingivalis and Campylobacter rectus in subgingival and atherosclerotic plaques of CABG surgery by using Polymerase Chain Reaction.

Methods

51 patients in the age group of 40 to 80 years with chronic periodontitis were recruited for the study. These patients were suffering from Coronary Artery Disease (CAD) and underwent...

Continue Reading...

Periodontal disease with treatment reduces subsequent cancer risks

This research was originally published in 2014 by Ing-Ming Hwang , Li-Min Sun , Cheng-Li Lin , Chun-Feng Lee , Chia-Hung Kao. 

We have curated this article as a reference point for The Larkin Protocol. 


ABSTRACT

Aim: The aim of our study was to evaluate the relationship between routine treatment of periodontal disease (PD) and the subsequent risks for cancers in Taiwan.

Methods: Study participants were selected from the Taiwan National Health Insurance (NHI) system database. The PD with a routine treatment cohort contained 38 902 patients. For each treatment cohort participant, two age- and sex-matched comparison (control) cohort participants were randomly selected. Cox's proportional hazards regression analysis was used to estimate the effects of PD with treatment on the subsequent risk of cancer.

Results: The overall risk of developing cancer was significantly lower in the treatment cohort than in the patients without treatment (adjusted Hazard ratio =...

Continue Reading...

Is Periodontitis a Risk Factor for Cognitive Impairment and Dementia? A Case-Control Study

This research was originally published in 2015 by José A. Gil-Montoya, Ines Sanchez-Lara, Cristobal Carnero-Pardo, Francisco Fornieles, Juan Montes, Rosa Vilchez, J. S. Burgos, M. A. Gonzalez-Moles, Rocío Barrios, Manuel Bravo. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Background: Dementia is a multi-etiologic syndrome characterized by multiple cognitive deficits but not always by the presence of cognitive impairment. Cognitive impairment is associated with multiple non-modifiable risk factors but few modifiable factors. Epidemiologic studies have shown an association between periodontitis, a potentially modifiable risk factor, and cognitive impairment. The objective of this study is to determine whether clinical periodontitis is associated with the diagnosis of cognitive impairment/dementia after controlling for known risk factors, including age, sex, and education level.

Methods: A case-control study was conducted...

Continue Reading...

Periodontitis and Cognitive Decline in Alzheimer’s Disease

This research was originally published in 2016 by Mark Ide,Marina Harris,Annette Stevens,Rebecca Sussams,Viv Hopkins,David Culliford,James Fuller,Paul Ibbett,Rachel Raybould,Rhodri Thomas,Ursula Puenter,Jessica Teeling,V. Hugh Perry,Clive Holmes. 

We have curated this article as a reference point for The Larkin Protocol.

ABSTRACT

Periodontitis is common in the elderly and may become more common in Alzheimer’s disease because of a reduced ability to take care of oral hygiene as the disease progresses. Elevated antibodies to periodontal bacteria are associated with an increased systemic pro-inflammatory state. Elsewhere raised serum pro-inflammatory cytokines have been associated with an increased rate of cognitive decline in Alzheimer’s disease. We hypothesized that periodontitis would be associated with increased dementia severity and a more rapid cognitive decline in Alzheimer’s disease. We aimed to determine if periodontitis in Alzheimer’s disease is...

Continue Reading...

Relationship Among Mothers’ Glycemic Level, Periodontitis, and Birth Weight

This research was originally published in 2016 by Isaac S. Gomes-Filho, Eliesita C. Pereira, Simone S. Cruz, Luis Fernando F. Adan, Maria Isabel P. Vianna, Johelle S. Passos-Soares, Soraya C. Trindade, Ernesto P. Oliveira, Michelle T. Oliveira, Eneida de M. M. Cerqueira, Antonio Luis Pereira, Maurício L. Barreto, Gregory John Seymour. 

We have curated this article as a reference point for The Larkin Protocol.


ABSTRACT

Background: The aim of this study is to determine the influence of glycemic level on the relationship between periodontitis and low birth weight (LBW).

Methods: A case-control study was conducted with 372 females divided into cases (109 mothers of newborns with birth weight <2,500 g) and controls (263 mothers of newborns with birth weight ≥2,500 g). The birth weight of children was obtained from medical records, whereas information on sociodemographic, lifestyle, and health characteristics of the participants was obtained through an...

Continue Reading...
1 2 3 4 5 6 7 8
Close

50% Complete

Two Step

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.